Ontario family history assessment tool
They can be used to guide referrals to genetic counseling for more definitive risk assessment. Onset age, y. Any age. Did any woman in your family have breast and ovarian cancer? Personal history: current age, age at menopause, age at menarche, child-birth history, menopausal status, use of menopausal hormone therapy.
Personal breast history, breast density optional , prior breast biopsy, history of cancer breast or ovarian , genetic testing. Family history genetic risk —relatives with breast or ovarian cancer, age at diagnosis, genetic testing. These include breast cancer diagnosis before age 50 years, bilateral breast cancer, presence of both breast and ovarian cancer in one individual, male family members with breast cancer, multiple cases of breast cancer in the family, 1 or more family members with 2 primary types of BRCA -related cancer such as ovarian cancer , and Ashkenazi Jewish ancestry.
The USPSTF recognizes that each risk assessment tool has advantages and limitations and found insufficient evidence to recommend one over another. Several professional organizations describe the skills and training necessary to provide comprehensive genetic counseling.
The type of mutation analysis required depends on family history. Individuals from families with known mutations or from ancestry groups in which certain mutations are more common e. The availability of testing options has changed since the U. The National Cancer Institute Cancer Genetics Services Directory provides a list of professionals who offer services related to cancer genetics, including cancer risk assessment, genetic counseling, and genetic testing.
This recommendation statement was first published in JAMA. Department of Health and Human Services, or the U. Public Health Service. Already a member or subscriber? Log in. Interested in AAFP membership? Learn more. Medicine Baltimore. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Wooster R, Weber BL.
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Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition. Lifetime risk for breast cancer doubles with a score of more than ten. A patient is required to complete the checklist only if she has any family history of breast or ovarian cancer. Patient is positive for screening and is referred for genetic counseling if 2 or more items in the above list are checked.
Score is given for every family member including second or third degree relative with a history of breast or ovarian cancer. Referral to genetic counseling is done with a score equal to or more than 8. Following questions should be asked in order to screen patients for presence of potentially harmful BRCA mutations:.
Refer to genetic counseling with one or more positive response. Ontario Ancestors is honoured to provide free webhosting to this important and independent Canadian genealogical resource. Read more ». This Web
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